The collagen substrate specificity of rat uterus collagenase.
نویسندگان
چکیده
منابع مشابه
Substrate Specificity of &Collagenase from CZostridium histolyticum”
The substrate specificity of #?-collagenase from Clostridium histolyticum has been investigated by measuring the rate of hydrolysis of more than 50 tri-, tetra-, penta-, and hexapeptides covering the P3 to Ps’ subsites of the substrate. The choice of peptides was patterned after sequences found in the a1 and a2 chains of type I collagen. Each peptide contained either a 2-furanacryloyl (FA) or c...
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In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate by this CDase. The results showed that, of the four possible stereoisomers of Cer, only the natural d-e-C(18)-Cer isomer was used as substrate...
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That rheumatic fever generally attacks children and rheumatoid arthritis usually occurs in adults may be due to an alteration in the target organ (collagen plus ground substance) with age. Perhaps young, growing collagen is more susceptible to the stimuli producing rheumatic fever, whilst the more metabolically inert adult collagen responds with rheumatoid change to factors as yet unknown. One ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)43838-5